Archer™ LIQUIDPlex™ Universal Solid Tumor panel
Detect important alterations for multiple cancers with one ctDNA panel
Find single nucleotide variants, insertions, deletions, and copy number variations in ctDNA with targeted NGS of 29 genes relevant for NSCLC, breast, colorectal, melanoma, and other solid tumor cancer research.
Pinpoint low-frequency variants with LIQUIDPlex NGS panels for ctDNA.
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Learn how the LIQUIDPlex Universal Solid Tumor panel can identify key genomic alterations for your research.
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Panel specifications
| Specifications | |
|---|---|
| Targeted genes | 29 |
| Genomic alterations | SNVs, Indels, CNVs |
| Input cfDNA required | ≥5 ng |
| Recommended number of reads | 5 M |
| Hands-on time | <3.5 hours |
| Total library prep time | 1.5 days |
| Platform compatibility | Illumina® |
| Reagent format | Lyophilized |
| Supported sample types | Plasma |
Gene targets
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Benefits
- Detect confidently—A unique outlier detection algorithm leverages position-specific data to enable variant detection even at low allele frequencies, one of the many ways that Archer Analysis empowers you to detect confidently.
- Less QNS—Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide range of sample types, including low-input samples such as cfDNA.
- Achieve efficiency—Parallel workflows across all Archer panels provides streamlined genomic characterization, while single use, reaction-sized lyophilized reagents minimize hands-on time and potential pipetting errors.
- Customize content—Work with our design experts to modify any panel to fit your lab's specific needs.
Ready to start?
Talk with our technical sales team. Learn how the LIQUIDPlex Universal Solid Tumor panel can identify key genomic alterations for your research.
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Frequently asked questions
What is the difference between Anchored Multiplex PCR (AMP™) and traditional priming methods for DNA NGS analysis?
As opposed to traditional priming methods, AMP chemistry enables tiling primers across both strands of DNA, optimally covering targeted regions for amplification and characterization of challenging, yet relevant alterations such as internal tandem duplications. Additionally, AMP chemistry uses molecular barcode adapters that bind to DNA fragments before amplification, allowing for efficient amplification of targets even from degraded or fragmented nucleic acid input, such as DNA from FFPE tissue and ctDNA from plasma.
How is LIQUIDPlex™ optimized to amplify cell free DNA (cfDNA) from plasma samples?
LIQUIDPlex assays, powered by Anchored Multiplex PCR (AMP™) chemistry, preferentially amplify low molecular weight cfDNA fragments. Adapters are ligated to end-repaired input cfDNA fragments prior to amplification with a gene specific primer and a universal primer at the adapter region. High molecular weight genomic DNA (gDNA) fragments in the input sample are too long for complete amplification, allowing for optimal amplification of cfDNA with LIQUIDPlex assays.
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