Archer™ IMMUNOVerse™ BCR panel
Assess clonalities, MRD, and more with a targeted RNA assay
Characterize B-cell clonalities, including isotypes and subclasses in the Fc region and somatic hypermutations within the variable regions, with targeted NGS of B-cell receptor chain RNA relevant for blood cancer and solid tumor research.
Clarify the immune repertoire with Archer IMMUNOVerse NGS Panels for RNA.
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Learn how the IMMUNOVerse BCR panel can identify key genomic alterations for your research.
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Panel specifications
| Specifications | |
|---|---|
| Target regions | BCR heavy (IGH) and light (kappa/lambda) chains |
| Applications | Clonality, MRD, profiling, somatic hypermutation |
| Input RNA required* | 20 ng to 6 μg |
| Recommended number of reads* | 250 K to 10 M |
| Hands-on time | 3.5 hours |
| Total library prep time | 1.5 days |
| Platform compatibility | Illumina® |
| Reagent format | Lyophilized |
| Supported sample types | Blood, PBMC, bone marrow, sorted B cells, FFPE, fresh frozen tissue |
*Input mass and read requirements vary depending on type, quality, B cell content, and application.
Benefits
- Secure data—Assessing samples in-house means you retain important data for further studies, ensuring all your data remains user-owned.
- Identify more—Anchored Multiplex PCR (AMP™) chemistry amplifies effectively through hypervariable sequences and variable length fragments enabling rare clone detection, even for potentially degraded FFPE tissue.
- Clarify confidently—Archer Analysis corrects for amplification bias and sequencing errors to provide a true and reproducible measure of diversity and can be used for disease monitoring, repertoire profiling, and somatic hypermutation detection.
- Achieve efficiency—Parallel workflows across all Archer panels provides streamlined genomic characterization, while single use, reaction-sized lyophilized reagents minimize hands-on time and potential pipetting errors.
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Talk with our technical sales team. Learn how the IMMUNOVerse BCR panel can identify key genomic alterations for your research.
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Frequently asked questions
Can I analyze DNA and RNA simultaneously for comprehensive genomic profiling of blood cancers with Archer panels?
Yes, DNA and RNA from a single sample can be analyzed with VARIANTPlex™ and FUSIONPlex™ panels to provide a genomic profile of the blood cancer. For comprehensive genomic profiling, pair FUSIONPlex Pan Heme and VARIANTPlex Myeloid panels to interrogate 226 genes for fusions, splicing, exon-skipping, SNVs, indels, CNVs, ITDs and expression levels. Additionally, IMMUNOVerse™ assays can provide T- and B-cell clonality, MRD, and somatic hypermutation information relevant for heme malignancies. IMMUNOVerse panels have parallel workflows with VARIANTPlex and FUSIONPlex assays, allowing for comprehensive, streamlined blood cancer profiling.
Can IMMUNOVerse™ assays detect somatic hypermutation in chronic lymphocytic leukemia?
Yes, the IMMUNOVerse BCR panel can detect somatic hypermutation relevant for determining subsets of cancer cell populations helpful in chronic lymphocytic leukemia (CLL) characterization. Gene specific primers bind the constant region of the B-cell receptor mRNA transcript and allow for amplification of the V(D)J region, including hypermutated V regions, and Archer™ Analysis reports hypermutation status for the most highly represented clonotypes.
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